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[IF:13.312]

A Dual PI3K/HDAC to

双PI3K/HDAC抑制剂诱导免疫原性铁死亡以加强癌症免疫检查点治疗

10.1158/0008-5472.CAN-21-1547

2021-12-15,

& :

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The of to exert a to novel for with to 。 In this study戒烟激活癌细胞, we a dual- PI3K and HDAC BEBT-908 that tumor cell and anti-PD1 in mice by in cells。 with BEBT-908 cell death of cells by p53 and the of 。

, BEBT-908 a tumor that host and 。 , BEBT-908- led to of MHC class I and of IFNγ in cells via the STAT1 。 The dual PI3K/HDAC BEBT-908 is a agent types that and the of 。

: The dual PI3K/HDAC BEBT-908 , of tumor cells and 。

First :

Fan

:

Liu

All :

Fan,Pei Liu,Rudi Bao,Jian Chen戒烟激活癌细胞, Zhou, Mo,Yaru Ma,Haiqi Liu, Zhou,Xiong Cai, Qian, Liu